Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Recurrent Mutations in a Single Exon Encoding the Evolutionarily Conserved Olfactomedin-Homology Domain of TIGR in Familial Open-Angle Glaucoma

1 Nov 1997

Abstract excerpt

Primary open-angle glaucoma (POAG) is a highly prevalent cause of irreversible blindness which associates cupping of the optic disc and alteration of the visual field, elevation of intraocular pressure being a major risk factor. Provided diagnosis is made at an early stage, treatments are available to prevent visual impairment. A locus, GLC1A, has been mapped on chromosome 1q23-q25 in several families affected...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glaucoma and retinal disorders
Share to Retinal Development and Disorders
Share to Retinal Diseases and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9328473
DOI: 10.1093/hmg/6.12.2091

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recurrent Mutations in a Single Exon Encoding the Evolutionarily Conserved Olfactomedin-Homology Domain of TIGR in Familial Open-Angle GlaucomaPMID 9328473Read ↗

GLC1A mutations point to regions of potential functional importance on the TIGR/MYOC protein.Semantic proximity Read ↗

Novel trabecular meshwork inducible glucocorticoid response mutation in an eight-generation juvenile-onset primary open-angle glaucoma pedigree.Semantic proximity Read ↗

Recent advances in molecular genetics of glaucomasSemantic proximity Read ↗

Molecular basis of open-angle glaucoma in Italy.Semantic proximity Read ↗

Age-dependent prevalence of mutations at the GLC1A locus in primary open-angle glaucoma.Semantic proximity Read ↗

Targeted Disruption of the Myocilin Gene (<i>Myoc</i>) Suggests that Human Glaucoma-Causing Mutations Are Gain of FunctionSemantic proximity Read ↗

Novel TIGR/MYOC mutations in families with juvenile onset primary open angle glaucoma.Semantic proximity Read ↗

Characterization and differential expression of a human gene family of olfactomedin-related proteinsSemantic proximity Read ↗

Identification of a new 'TIGR' mutation in a family with juvenile-onset primary open angle glaucoma.Semantic proximity Read ↗

Cloning and characterization of subtracted cDNAs from a human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedinSemantic proximity Read ↗

Keeping an Eye on Myocilin: A Complex Molecule Associated with Primary Open-Angle Glaucoma SusceptibilitySemantic proximity Read ↗

A multidomain TIGR/olfactomedin protein family with conserved structural similarity in the N-terminal region and conserved motifs in the C-terminal region.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.