Article
Association of a single nucleotide polymorphism in the TIGR/MYOCILIN gene promoter with the severity of primary open-angle glaucoma.
Clinical genetics - 1 Sept 2001
Colomb E, Nguyen T D, Béchetoille A, Dascotte J C, Valtot F, Brézin A P, Berkani M, Copin B, Gomez L, Polansky J R, Garchon H J
Abstract excerpt
Primary open-angle glaucoma (POAG) is a highly prevalent optic neuropathy and a major cause of irreversible blindness, with elevation of intraocular pressure (IOP) being a primary risk factor. The trabecular meshwork-inducible glucocorticoid response (TIGR)/MYOCILIN (MYOC) gene coding region is mutated in 3-4% of POAG patients. Here, in a retrospective study of 142 POAG patients, we evaluated the influence on...
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