Article
Pathogenic Variants in Selenoproteins and Selenocysteine Biosynthesis Machinery.
International journal of molecular sciences - 27 Oct 2021
Santesmasses Didac, Gladyshev Vadim N
Abstract excerpt
Selenium is incorporated into selenoproteins as the 21st amino acid selenocysteine (Sec). There are 25 selenoproteins encoded in the human genome, and their synthesis requires a dedicated machinery. Most selenoproteins are oxidoreductases with important functions in human health. A number of disorders have been associated with deficiency of selenoproteins, caused by mutations in selenoprotein genes or Sec...
Topics
Join the communities discussing this publication.