Article
Structural and functional identification of major histocompatibility complex class I-restricted self-peptides as naturally occurring molecular mimics of viral antigens. Possible role in CD8+ T cell-mediated, virus-induced autoimmune disease.
The Journal of biological chemistry - 1 Jun 2001
Hudrisier D, Riond J, Burlet-Schiltz O, von Herrath M G, Lewicki H, Monsarrat B, Oldstone M B, Gairin J E
Abstract excerpt
Structural similarity (molecular mimicry) between viral epitopes and self-peptides can lead to the induction of autoaggressive CD4(+) as well as CD8(+) T cell responses. Based on the flexibility of T cell receptor/antigen/major histocompatibility complex recognition, it has been proposed that a s...
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