Article
Detection of sequence variability of the collagen type IIalpha 1 3' variable number of tandem repeat.
Electrophoresis - 1 Nov 2000
van Meurs J B, Arp P P, Fang Y, Slagboom P E, Meulenbelt I, van Leeuwen J P, Pols H A, Uitterlinden A G
Abstract excerpt
The variable number of tandem repeat (VNTR) 3' of the collagen type II (COL2A1) gene has been shown to be highly variable with a complex molecular structure. In a previous pilot experiment we observed discordance between methods to genotype this informative marker. To further investigate the extent and molecular nature of this discordance, we genotyped a random sample of 207 Caucasian individuals with two...
Topics
- Aged
- Alleles
- Base Sequence
- Collagen
- DNA, Single-Stranded
- Female
- Genetic Variation
- Heteroduplex Analysis
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Nucleic Acid Heteroduplexes
- Sequence Analysis, DNA
- Tandem Repeat Sequences