Heteroduplex analysis can increase the informativeness of PCR-amplified VNTR markers: application using a marker tightly linked to the COL2A1 gene.

doi:10.1006/geno.1993.1070

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Article

Heteroduplex analysis can increase the informativeness of PCR-amplified VNTR markers: application using a marker tightly linked to the COL2A1 gene.

Genomics - 1 Feb 1993

Wilkin D J, Koprivnikar K E, Cohn D H

Abstract excerpt

Variable number of tandem repeat (VNTR) polymorphisms provide a high degree of informativeness in linkage studies. Whether performed by standard methods or by polymerase chain reaction (PCR), analysis of these markers involves assessment of the length of each allele. VNTR alleles usually differ i...

Topics

Alleles
Base Sequence
Cells, Cultured
Collagen
DNA, Single-Stranded
Female
Genetic Markers
Homozygote
Humans
Male
Molecular Sequence Data
Nucleic Acid Heteroduplexes
Pedigree
Polymerase Chain Reaction
Polymorphism, Genetic
Repetitive Sequences, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 8449503
DOI: 10.1006/geno.1993.1070

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8449503-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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