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Article

Regulation of tamoxifen sensitivity by a PAK1-EBP1 signalling pathway in breast cancer.

British journal of cancer - 19 Feb 2013

Ghosh A, Awasthi S, Peterson J R, Hamburger A W

Abstract excerpt

BACKGROUND: EBP1, an ErbB3-binding protein, sensitises breast cancer cells to tamoxifen in part by decreasing ErbB2 protein levels. The p21-regulated serine/threonine kinase PAK1, implicated in tamoxifen resistance, phosphorylates EBP1 in vitro and in vivo at T261. Phosphorylation of EBP1 at this site induces tamoxifen resistance. We thus postulated that inhibition of PAK1 activity, by restoring EBP1 function,...

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Share to Adaptor Proteins, Signal Transducing
Share to Antineoplastic Agents, Hormonal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Fluorescent Antibody Technique

Share to p21-Activated Kinases

Share to Receptor, ErbB-2

Share to RNA-Binding Proteins

Share to Tamoxifen

Source

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Identifiers

PMID: 23361053
DOI: 10.1038/bjc.2013.11
PMCID: PMC3593557

Genes

PAK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of tamoxifen sensitivity by a PAK1-EBP1 signalling pathway in breast cancer.PMID 23361053Read ↗

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