Article
Mutational Analysis of Bile Cell-Free DNA in Primary Sclerosing Cholangitis: A Pilot Study.
Liver international : official journal of the International Association for the Study of the Liver - 1 Apr 2025
Arechederra Maria, Bik Emil, Rojo Carla, Elurbide Jasmin, Elizalde María, Kruk Beata, Krasnodębski Maciej, Pertkiewicz Jan, Kozieł Sławomir, Grąt Michał, Raszeja-Wyszomirska Joanna, Rullan Maria, Alkorta-Aranburu Gorka, Oyón Daniel, Fernández-Barrena Maite G, Candels Lena S, Białek Andrzej, Krupa Łukasz, Schneider Kai M, Urman Jesús, Strnad Pavel, Trautwein Christian, Milkiewicz Piotr, Krawczyk Marcin, Ávila Matías A, Berasain Carmen
Abstract excerpt
BACKGROUND: Primary sclerosing cholangitis (PSC) is a chronic liver disease characterised by inflammation and fibrosis of the bile ducts, conferring an increased risk of cholangiocarcinoma (CCA). However, detecting CCA early in PSC patients remains challenging due to the limited sensitivity of conventional diagnostic methods, including imaging or bile duct brush cytology during endoscopic retrograde...
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