Article
Mutations in NS5A region of hepatitis C virus genome correlate with presence of NS5A antibodies and response to interferon therapy for most common European hepatitis C virus genotypes.
Hepatology (Baltimore, Md.) - 1 Dec 1998
Frangeul L, Cresta P, Perrin M, Lunel F, Opolon P, Agut H, Huraux J M
Abstract excerpt
A part of the hepatitis C virus (HCV) nonstructural protein 5A (NS5A) amino acid sequence, designated as an interferon (IFN)-sensitive determining region (ISDR), has been shown to be correlated with a response to IFN in Japanese patients. We have shown previously that the presence of NS5A antibod...
Topics
- Amino Acid Sequence
- Antibodies
- Antiviral Agents
- Drug Resistance
- Genome, Viral
- Genotype
- Hepacivirus
- Hepatitis C
- Humans
- Interferon-alpha
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Viral Nonstructural Proteins