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Article

Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway.

The Journal of biological chemistry - 1 Jun 2001

Sugihara T, Kaul S C, Kato J, Reddel R R, Nomura H, Wadhwa R

Abstract excerpt

We isolated a 33-kDa protein, Pex19p/HK33/HsPXF, as a p19ARF-binding protein in a yeast two-hybrid screen. We demonstrate here that Pex19p interacts with p19ARF in the cell cytoplasm and excludes p19ARF from the nucleus, leading to a concurrent inactivation of p53 function. Down-regulation of Pex...

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Identifiers

PMID: 11259404
DOI: 10.1074/jbc.C100011200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11259404-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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