Article
Polymorphisms associated with apolipoprotein B levels in Greek patients with familial hypercholesterolemia.
Clinical chemistry and laboratory medicine - 1 Jan 2006
Choumerianou Despoina M, Maumus Sandy, Skoumas John, Pitsavos Christos, Stefanadis Christodoulos, Visvikis-Siest Sophie, Dedoussis George V Z
Abstract excerpt
BACKGROUND: Familial hypercholesterolemia (FH) is a genetic disorder characterized by high low-density lipoprotein-cholesterol (LDL-C) concentrations, which frequently gives rise to premature coronary artery disease. The clinical expression of FH is highly variable, even in patients carrying the same LDL receptor (LDLR) gene mutation. This variability may be due to environmental and other genetic factors....
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