Article
The risk of coronary artery disease in population of Taiwan is associated with Cys-Ser 311 polymorphism of human paraoxonase (PON)-2 gene.
Zhonghua yi xue za zhi = Chinese medical journal; Free China ed - 1 Sept 2002
Pan Ju-Pin, Lai Shiau-Ting, Chiang Shu-Chiung, Chou Shiu-Chin, Chiang An-Na
Abstract excerpt
BACKGROUND: Paraoxonase (PON), a high density lipoprotein (HDL)-associated enzyme, is capable of inhibiting low density lipoprotein (LDL) oxidation by destroying the biologically active phospholipids in oxidatively modified LDL. An increased risk of coronary artery disease (CAD) has shown to associate with polymorphisms of PON gene (PON1) in different population. The risk of CAD associated with the other...
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