Article
On the use of population-based registries in the clinical validation of genetic tests for disease susceptibility.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jan 2000
Yang Q, Khoury M J, Coughlin S S, Sun F, Flanders W D
Abstract excerpt
PURPOSE: Many new genetic tests for susceptibility to adult-onset diseases are developed on the basis of selected and high-risk groups. Before such tests can be used in medical practice, however, epidemiologic studies must be conducted to evaluate their clinical sensitivity, specificity, and positive predictive value in the general population. For many common adult-onset diseases, this process may take decades of...
Topics
- Adult
- Breast Neoplasms
- Case-Control Studies
- Female
- Genes, BRCA1
- Genetic Markers
- Genetic Predisposition to Disease
- Genetic Techniques
- Genetic Testing
- Genetics, Population
- Genotype
- Humans
- Methylenetetrahydrofolate Reductase (NADPH2)