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<b>A new immunosuppressant, FTY720, induces <i>bcl‐2</i>‐associated apoptotic cell death in human lymphocytes</b>

1 Dec 1996

Abstract excerpt

FTY720 is a unique immunosuppressive drug produced by modification of a metabolite from Isaria sinclairii. In vitro treatment of human mononuclear cells with FTY720 resulted in a dose-dependent reduction of cell viability. These treated cells demonstrated characteristic DNA ladder formation on agarose gel electrophoresis. Jurkat cells transfected with human bcl-2 gene were resistant to FTY720; their neo type was...

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Identifiers

PMID: 9014815
DOI: 10.1046/j.1365-2567.1996.d01-777.x

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