Article
Reverse transcriptase-based DNA vaccines against drug-resistant HIV-1 tested in a mouse model.
Vaccine - 16 Apr 2004
Isaguliants Maria G, Zuber Bartek, Boberg Andreas, Sjöstrand Dan, Belikov Sergey V, Rollman Erik, Zuber Anne Kjerrström, Rechinsky Vladimir O, Rytting Ann-Sofie, Källander Clas F R, Hinkula Jorma, Kochetkov Sergey N, Liu Margaret, Wahren Britta
Abstract excerpt
Drug resistance is becoming a problem in the treatment of the human immunodeficiency virus type one (HIV-1). To obtain therapeutic DNA vaccines that would target multiple drug-resistance (DR) mutations, we cloned genes for DR HIV-1 reverse transcriptase (RT) and codon-optimized synthetic genes en...
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