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Article

Immunogenicity of West Nile virus infectious DNA and its noninfectious derivatives.

Virology - 1 Jan 2000

Seregin Alexey, Nistler Ryan, Borisevich Victoria, Yamshchikov Galina, Chaporgina Elena, Kwok Chun Wai, Yamshchikov Vladimir

Abstract excerpt

The exceptionally high virulence of the West Nile NY99 strain makes its suitability in the development of a live WN vaccine uncertain. The aim of this study is to investigate the immunogenicity of noninfectious virus derivatives carrying pseudolethal mutations, which preclude virion formation without affecting preceding steps of the viral infectious cycle. When administered using DNA immunization, such constructs...

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Identifiers

PMID: 16935318
DOI: 10.1016/j.virol.2006.07.038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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