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Article

Positive regulation of Wee1 by Chk1 and 14-3-3 proteins.

Molecular biology of the cell - 1 Mar 2001

Lee J, Kumagai A, Dunphy W G

Abstract excerpt

Wee1 inactivates the Cdc2-cyclin B complex during interphase by phosphorylating Cdc2 on Tyr-15. The activity of Wee1 is highly regulated during the cell cycle. In frog egg extracts, it has been established previously that Xenopus Wee1 (Xwee1) is present in a hypophosphorylated, active form during interphase and undergoes down-regulation by extensive phosphorylation at M-phase. We report that Xwee1 is also...

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Identifiers

PMID: 11251070
DOI: 10.1091/mbc.12.3.551
PMCID: PMC30963

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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