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Article

5' cloverleaf in poliovirus RNA is a cis-acting replication element required for negative-strand synthesis.

The EMBO journal - 15 Mar 2001

Barton D J, O'Donnell B J, Flanegan J B

Abstract excerpt

A cloverleaf structure at the 5' terminus of poliovirus RNA binds viral and cellular proteins. To examine the role of the cloverleaf in poliovirus replication, we determined how cloverleaf mutations affected the stability, translation and replication of poliovirus RNA in HeLa S10 translation-replication reactions. Mutations within the cloverleaf destabilized viral RNA in these reactions. Adding a 5' 7-methyl...

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Identifiers

PMID: 11250909
DOI: 10.1093/emboj/20.6.1439
PMCID: PMC145522

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Source receipt: pubmed, retrieved 7 Sept 2026.

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