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Article

Functional role of the 5' terminal cloverleaf in Coxsackievirus RNA replication.

Virology - 25 Oct 2009

Sharma Nidhi, Ogram Sushma A, Morasco B Joan, Spear Allyn, Chapman Nora M, Flanegan James B

Abstract excerpt

Using cell-free reactions, we investigated the role of the 5' cloverleaf (5'CL) and associated C-rich sequence in Coxsackievirus B3 RNA replication. We showed that the binding of poly(C) binding protein (PCBP) to the C-rich sequence was the primary determinant of RNA stability. In addition, inhibition of negative-strand synthesis was only observed when PCBP binding to both stem-loop 'b' and the C-rich sequence...

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Identifiers

PMID: 19732932
DOI: 10.1016/j.virol.2009.07.039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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