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Article

Signatures of Host mRNA 5′ Terminus for Efficient Hantavirus Cap Snatching

12 Jul 2012

Abstract excerpt

Hantaviruses, similarly to other negative-strand segmented RNA viruses, initiate the synthesis of translation-competent capped mRNAs by a unique cap-snatching mechanism. Hantavirus nucleocapsid protein (N) binds to host mRNA caps and requires four nucleotides adjacent to the 5' cap for high-affinity binding. N protects the 5' caps of cellular transcripts from degradation by the cellular decapping machinery. The...

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PMID: 22787213
DOI: 10.1128/jvi.05560-11

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