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Article

Association of the Kir6.2 E23K variant with reduced acute insulin response in African-Americans.

The Journal of clinical endocrinology and metabolism - 1 Dec 2008

Palmer Nicholette D, Langefeld Carl D, Bryer-Ash Michael, Rotter Jerome I, Taylor Kent D, Bowden Donald W

Abstract excerpt

CONTEXT: ATP-sensitive potassium channels are composed of pore-forming (Kir6.x) and regulatory sulfonylurea receptor (SURx) subunits and have been implicated in the maintenance of glucose homeostasis. Kir6.2 and SUR1 are expressed in a broad range of tissues, and no contemporary studies have addr...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18796522
DOI: 10.1210/jc.2008-0543
PMCID: PMC2626454

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18796522-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of the Kir6.2 E23K variant with reduced acute insulin response in African-Americans.PMID 18796522Read ↗

Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study.Semantic proximity Read ↗

The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes.Semantic proximity Read ↗

Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance.Semantic proximity Read ↗

Identification of quantitative trait loci for glucose homeostasis: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study.Semantic proximity Read ↗

Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) genes predict the conversion from impaired glucose tolerance to type 2 diabetes. The Finnish Diabetes Prevention Study.Semantic proximity Read ↗

Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region.Semantic proximity Read ↗

INSIG2 SNPs associated with obesity and glucose homeostasis traits in Hispanics: the IRAS Family Study.Semantic proximity Read ↗

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.Semantic proximity Read ↗

A genome-wide association scan for acute insulin response to glucose in Hispanic-Americans: the Insulin Resistance Atherosclerosis Family Study (IRAS FS).Semantic proximity Read ↗

Current status of the E23K Kir6.2 polymorphism: implications for type-2 diabetesSemantic proximity Read ↗

The prevalent Glu23Lys polymorphism in the potassium inward rectifier 6.2 (KIR6.2) gene is associated with impaired glucagon suppression in response to hyperglycemia.Semantic proximity Read ↗

A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1.Semantic proximity Read ↗

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