Article
Genetic instability in bladder cancer assessed by the comet assay.
Journal of the National Cancer Institute - 2 Apr 2003
Schabath Matthew B, Spitz Margaret R, Grossman H Barton, Zhang Kerang, Dinney Colin P, Zheng Ping-Ju, Wu Xifeng
Abstract excerpt
BACKGROUND: Latent genetic instability has been associated with an increased risk for several cancers. We used the comet assay (single-cell gel electrophoresis) to assess whether genetic instability, as reflected by susceptibility to DNA damage, was associated with the risk of bladder cancer in a case-control study. METHODS: We used the comet assay to measure baseline and benzo[a]pyrene diol epoxide (BPDE)- and...
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