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Article

HBcAg-specific CD8 T cells play an important role in virus suppression, and acute flare-up is associated with the expansion of activated memory T cells.

Journal of clinical immunology - 1 May 2003

Shimada Noriaki, Yamamoto Kazuhide, Kuroda Marcelo J, Terada Ryo, Hakoda Tomomi, Shimomura Hiroyuki, Hata Hidenori, Nakayama Eiichi, Shiratori Yasushi

Abstract excerpt

We analyzed the prevalence and longitudinal fluctuation of hepatitis B virus (HBV)-specific CD8 T cells in chronic HBV infection using an HLA-A2-HBc18-27 tetramer. Thirty-five HLA-A2-positive patients with chronic HBV infection were divided into 17 HBe antigen (HBeAg)-positive and 18 anti-HBe antibody (anti-HBe)-positive patients. Five HLA-A2-positive normal subjects, five HLA-A2-negative patients with chronic...

Topics

Adult
Alanine Transaminase
CD8-Positive T-Lymphocytes
Chronic Disease
DNA, Viral
Female
Flow Cytometry
HLA-A2 Antigen
Hepatitis B
Hepatitis B Core Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hepatitis B e Antigens

Hepatitis B virus

Humans

Immunologic Memory

Liver

Male

Middle Aged

Phenotype

Source

Identifiers

PMID: 12797544
DOI: 10.1023/a:1023366013858

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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HBcAg-specific CD8 T cells play an important role in virus suppression, and acute flare-up is associated with the expansion of activated memory T cells.PMID 12797544Read ↗

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