Article
[TSH receptors and signal transduction].
Nihon rinsho. Japanese journal of clinical medicine - 1 Oct 1993
Kawakami Y, Fujita R, Okuda Y, Yamashita K
Abstract excerpt
The TSH receptors constitute one of the main part of the signal transduction in thyroid cells and are the main biochemical targets in pathological changes. Recent molecular cloning of the TSH receptor and site-directed mutagenesis experiments have provided new evidence. It is well-established that TSH activates the cAMP cascade. Recent evidence however suggests that TSH can also activate the PIP2 cascade, but not...
Topics
- Cloning, Molecular
- Cyclic AMP
- GTP-Binding Proteins
- Humans
- Mutation
- Receptors, Thyrotropin
- Signal Transduction
- Thyroid Diseases
- Thyrotropin