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Article

Effect of Chronic Uremia on the Cell Surface Expression of B7 Family Costimulatory Molecules in an HLA-A2 Transgenic Mouse Model of Chronic Kidney Disease.

Comparative medicine - 1 Aug 2015

Makidon Paul E, Smith Douglas M, Groom Ii Jeffery V, Cao Zhengyi, Landers Jeffery J, Baker James R

Abstract excerpt

Uremia due to chronic kidney disease (CKD) in humans is associated with immune dysfunction, increased susceptibility to infections, immune-activation-associated inflammation, and poor responses to vaccines. The pathophysiologic basis of these immune defects is hypothesized to be associated with a wide range of immunologic abnormalities, including an inability to sufficiently express the B7 family (B7-1, CD80;...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26310460
PMCID: PMC4549676

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