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Article

Mutations in pancreatic ß-cell Glucokinase as a cause of hyperinsulinaemic hypoglycaemia and neonatal diabetes mellitus.

Reviews in endocrine & metabolic disorders - 1 Sept 2010

Hussain Khalid

Abstract excerpt

Glucokinase is a key enzyme involved in regulating insulin secretion from the pancreatic ß-cell. The unique role of glucokinase in human glucose physiology is illustrated by the fact that genetic mutations in glucokinase can either cause hyperglycaemia or hypoglycaemia. Heterozygous inactivating mutations in glucokinase cause maturity-onset diabetes of the young (MODY), homozygous inactivating in glucokinase...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20878480
DOI: 10.1007/s11154-010-9147-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in pancreatic ß-cell Glucokinase as a cause of hyperinsulinaemic hypoglycaemia and neonatal diabetes mellitus.PMID 20878480Read ↗

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Identification of 14 new glucokinase mutations and description of the clinical profile of 42 MODY-2 families.Semantic proximity Read ↗

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Identification of two new mutations in the glucokinase gene that result in maturity-onset diabetes of the young.Semantic proximity Read ↗

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