Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Is there a threshold of hepatic iron concentration that leads to cirrhosis in C282Y hemochromatosis?

The American journal of gastroenterology - 1 Feb 2001

Adams P C

Abstract excerpt

OBJECTIVE: The relationship between the degree of iron overload and the presence of cirrhosis has not been clearly established in hemochromatosis. Severe iron overload occurs without cirrhosis and moderate iron overload can occur with cirrhosis. Previous estimates may have overestimated the problem because of the overdiagnosis of hemochromatosis in patients with alcoholic liver disease and chronic viral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Hemochromatosis
Share to Homozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Iron Overload

Share to Liver Cirrhosis

Share to ROC Curve

Share to Sensitivity and Specificity

Source

Identifiers

PMID: 11232708
DOI: 10.1111/j.1572-0241.2001.03472.x

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Is there a threshold of hepatic iron concentration that leads to cirrhosis in C282Y hemochromatosis?PMID 11232708Read ↗

Cirrhosis in Hemochromatosis: Independent Risk Factors in 368 HFE p.C282Y Homozygotes.Semantic proximity Read ↗

Serum ferritin level predicts advanced hepatic fibrosis among U.S. patients with phenotypic hemochromatosis.Semantic proximity Read ↗

C282Y mutation and hepatic iron status in hepatitis C and cryptogenic cirrhosis.Semantic proximity Read ↗

Penetrance of the C28Y/C282Y genotype of the HFE gene.Semantic proximity Read ↗

Hepatic iron overload in alcoholic end-stage liver disease is associated with iron deposition in other organs in the absence of HFE-1 hemochromatosis.Semantic proximity Read ↗

Clinical penetrance in hereditary hemochromatosis: estimates of the cumulative incidence of severe liver disease among HFE C282Y homozygotes.Semantic proximity Read ↗

End-stage liver disease without hemochromatosis associated with elevated hepatic iron index.Semantic proximity Read ↗

Abdominal pain and cirrhosis at diagnosis of hemochromatosis: Analysis of 219 referred probands with HFE p.C282Y homozygosity and a literature review.Semantic proximity Read ↗

Liver iron, HFE gene mutations, and hepatocellular carcinoma occurrence in patients with cirrhosis.Semantic proximity Read ↗

Differences in hepatic phenotype between hemochromatosis patients with HFE C282Y homozygosity and other HFE genotypes.Semantic proximity Read ↗

Diagnosis of hemochromatosis.Semantic proximity Read ↗

Non-HFE iron overload as a surrogate marker of disease severity in patients of liver cirrhosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.