Article
Epidermal growth factor receptor induced apoptosis: potentiation by inhibition of Ras signaling.
FEBS letters - 23 Feb 2001
Högnason T, Chatterjee S, Vartanian T, Ratan R R, Ernewein K M, Habib A A
Abstract excerpt
Previous studies have shown that certain tumor cell lines which naturally express high levels of the epidermal growth factor receptor (EGFR) undergo apoptosis when exposed to epidermal growth factor. Whether this phenomenon is a direct result of receptor overexpression or some other genetic alteration renders these cells sensitive to apoptosis is yet to be established. We show that experimentally increasing the...
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