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Article

Characterization of the neurotrophic interaction between nerve growth factor and secreted alpha-amyloid precursor protein.

Journal of neuroscience research - 1 Mar 2001

Luo J J, Wallace M S, Hawver D B, Kusiak J W, Wallace W C

Abstract excerpt

The expression and secretion of amyloid precursor protein (beta APP) is increased in rat cerebral cortices that have been denervated by subcortical lesions of the nucleus basalis of Meynert. The physiological role of the secreted beta APP in response to this injury has not been established. We have previously shown that secreted beta APP produced by alpha-secretase activity (sAPP(alpha)) potentiates the...

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Identifiers

PMID: 11223916
DOI: 10.1002/1097-4547(20010301)63:5<410::AID-JNR1036>3.0.CO;2-B

Genes

NGF
APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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