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Article

Neuroprotective effect of the PACAP-ADNP axis on SOD1G93A mutant motor neuron death induced by trophic factors deprivation.

Neuropeptides - 1 Dec 2023

Magrì Benedetta, D'Amico Agata Grazia, Maugeri Grazia, Morello Giovanna, La Cognata Valentina, Saccone Salvatore, Federico Concetta, Cavallaro Sebastiano, D'Agata Velia

Abstract excerpt

Amyotrophic lateral Sclerosis (ALS) is a neurodegenerative disease characterized by progressive degeneration of motor neurons in the central nervous system. Mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1) account for approximately in 20% of familial ALS cases. The pathological mechanisms underlying the toxicity induced by mutated SOD1 are still unknown. However, it has been hypothesized that...

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PMID: 37856900
DOI: 10.1016/j.npep.2023.102386

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