Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

E2 proteins from high- and low-risk human papillomavirus types differ in their ability to bind p53 and induce apoptotic cell death.

Journal of virology - 1 May 2006

Parish Joanna L, Kowalczyk Anna, Chen Hsin-Tien, Roeder Geraldine E, Sessions Richard, Buckle Malcolm, Gaston Kevin

Abstract excerpt

The E2 proteins from oncogenic (high-risk) human papillomaviruses (HPVs) can induce apoptotic cell death in both HPV-transformed and non-HPV-transformed cells. Here we show that the E2 proteins from HPV type 6 (HPV6) and HPV11, two nononcogenic (low-risk) HPV types, fail to induce apoptosis. Unlike the high-risk HPV16 E2 protein, these low-risk E2 proteins fail to bind p53 and fail to induce p53-dependent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Models, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Papillomaviridae

Share to Protein Binding

Share to Protein Structure, Tertiary

Share to Transcription, Genetic

Share to Tumor Suppressor Protein p53

Share to Viral Envelope Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 16611918
DOI: 10.1128/JVI.80.9.4580-4590.2006
PMCID: PMC1472007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

E2 proteins from high- and low-risk human papillomavirus types differ in their ability to bind p53 and induce apoptotic cell death.PMID 16611918Read ↗

The human papillomavirus (HPV) 16 E2 protein induces apoptosis in the absence of other HPV proteins and via a p53-dependent pathway.Semantic proximity Read ↗

Human papillomavirus (HPV) E6 interactions with Bak are conserved amongst E6 proteins from high and low risk HPV types.Semantic proximity Read ↗

The Human Papillomavirus 16 E6 Protein Binds to Tumor Necrosis Factor (TNF) R1 and Protects Cells from TNF-induced ApoptosisSemantic proximity Read ↗

Functional consequences of directed mutations in human papillomavirus E6 proteins: abrogation of p53-mediated cell cycle arrest correlates with p53 binding and degradation in vitro.Semantic proximity Read ↗

Human papillomavirus oncoproteins and apoptosis (Review)Semantic proximity Read ↗

P53 represses human papillomavirus type 16 DNA replication via the viral E2 protein.Semantic proximity Read ↗

Transcription-independent triggering of the extrinsic pathway of apoptosis by human papillomavirus 18 E2 protein.Semantic proximity Read ↗

Modulation of Apoptotic Pathways by Human Papillomaviruses (HPV): Mechanisms and Implications for TherapySemantic proximity Read ↗

Apoptosis in human papillomavirus16 E7-, but not E6-immortalized human uroepithelial cells.Semantic proximity Read ↗

Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activationSemantic proximity Read ↗

The role of human papillomavirus oncoproteins E6 and E7 in apoptosisSemantic proximity Read ↗

Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.