Apoptosis in human papillomavirus16 E7-, but not E6-immortalized human uroepithelial cells.

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Article

Apoptosis in human papillomavirus16 E7-, but not E6-immortalized human uroepithelial cells.

Oncogene - 19 Sept 1996

Puthenveettil J A, Frederickson S M, Reznikoff C A

Abstract excerpt

We compared the ability of E6-, versus E7-, immortalized human uroepithelial cells (HUC) to undergo apoptosis in response to gamma radiation. Two independent HPV16 E6-immortalized cell lines, alphaE6#1 and alphaE6#2, that showed low or undetectable p53 levels, failed to undergo apoptosis in respo...

Topics

Apoptosis
Cell Cycle
Cell Line, Transformed
Cell Transformation, Viral
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
Epithelial Cells
Epithelium
Humans
Mutation
Oncogene Proteins, Viral
Papillomaviridae
Papillomavirus E7 Proteins
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
Repressor Proteins
Tumor Suppressor Protein p53
Urinary Tract

Source

Open in PubMed

Identifiers

PMID: 8808685

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8808685-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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