Article
Role of intercellular adhesion molecule-1 in antigen-induced lung inflammation in brown Norway rats.
The American journal of physiology - 1 Aug 1996
Richards I M, Kolbasa K P, Winterrowd G E, Hatfield C A, Vonderfecht S L, Fidler S F, Griffin R L, Brashler J R, Krzesicki R F, Lane C L, Anderson D C, Sly L M, Staite N D, Chin J E
Abstract excerpt
We investigated the involvement of intercellular adhesion molecule-1 (ICAM-1; CD54) in ovalbumin (OA) antigen-induced lung inflammation in sensitized Brown Norway (BN) rats by using flow cytometry and in vivo treatment with a murine monoclonal antibody (MAb), 1A29, directed against rat ICAM-1. OA-challenge induced an eosinophil and lymphocyte-rich accumulation of leukocytes into the airway lumen. Between 75 and...
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