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Article

The Salmonella spvB virulence gene encodes an enzyme that ADP-ribosylates actin and destabilizes the cytoskeleton of eukaryotic cells.

Molecular microbiology - 1 Mar 2001

Lesnick M L, Reiner N E, Fierer J, Guiney D G

Abstract excerpt

ADP-ribosylating enzymes, such as cholera and diphtheria toxins, are key virulence factors for a variety of extracellular bacterial pathogens but have not been implicated previously during intracellular pathogenesis. Salmonella strains are capable of invading epithelial cells and localizing in macrophages during infection. The spvB virulence gene of Salmonella is required for human macrophage cytotoxicity in...

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PMID: 11260464
DOI: 10.1046/j.1365-2958.2001.02360.x

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