Article
Polynucleotide phosphorylase negatively controls spv virulence gene expression in Salmonella enterica.
Infection and immunity - 1 Feb 2006
Ygberg Sofia Eriksson, Clements Mark O, Rytkönen Anne, Thompson Arthur, Holden David W, Hinton Jay C D, Rhen Mikael
Abstract excerpt
Mutational inactivation of the cold-shock-associated exoribonuclease polynucleotide phosphorylase (PNPase; encoded by the pnp gene) in Salmonella enterica serovar Typhimurium was previously shown to enable the bacteria to cause chronic infection and to affect the bacterial replication in BALB/c mice (M. O. Clements et al., Proc. Natl. Acad. Sci. USA 99:8784-8789, 2002). Here, we report that PNPase deficiency...
Topics
- Animals
- Bacterial Proteins
- Cell Line
- Female
- Gene Expression Profiling
- Gene Expression Regulation, Bacterial
- Macrophages
- Mice
- Mice, Inbred BALB C
- Mutation
- Oligonucleotide Array Sequence Analysis
- Plasmids
- Polyribonucleotide Nucleotidyltransferase