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Article

Gene expression in single cells of Bacillus subtilis: evidence that a threshold mechanism controls the initiation of sporulation.

Journal of bacteriology - 1 Apr 1994

Chung J D, Stephanopoulos G, Ireton K, Grossman A D

Abstract excerpt

Early during endospore formation in the bacterium Bacillus subtilis, two distinct cell types are formed. The initiation of this developmental pathway requires several physiological conditions (e.g., nutrient deprivation) and is controlled by the Spo0A transcription factor. We have found that in a culture of sporulating cells, there are two subpopulations, one that has initiated the developmental program and...

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Identifiers

PMID: 8144465
DOI: 10.1128/jb.176.7.1977-1984.1994
PMCID: PMC205302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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