Article
Computer simulation analysis suggests weak balancing selection operative at the MICA locus.
Hereditas - 1 Jan 2000
Ohashi J, Tokunaga K
Abstract excerpt
A high degree of polymorphism has been reported at the major histocompatibility class I chain-related gene A (MICA) locus, which is located 46 kb away from HLA-Bin the human major histocompatibility complex (MHC) class I region. Although it is known that the polymorphisms at the conventional MHC class I loci have been maintained by balancing selection, it is unclear whether positive natural selection is also...
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