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Article

Somatic hypermutation and B-cell lymphoma.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Jan 2001

Dunn-Walters D, Thiede C, Alpen B, Spencer J

Abstract excerpt

During the B-cell response to T-cell-dependent antigens, the B cells undergo a rapid proliferative phase in the germinal centre. This is accompanied by the introduction of mutations into the immunoglobulin (Ig) variable region (V) genes. The B cells are then selected according to the affinity of the encoded immunoglobulin for antigen, resulting in affinity maturation of the response. Analysis of mutations in IgV...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11205334
DOI: 10.1098/rstb.2000.0751
PMCID: PMC1087694

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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