Article
Germline variations of the MALT1 gene as risk factors in the development of primary gastric B-cell lymphoma.
European journal of cancer (Oxford, England : 1990) - 1 Jul 2009
Hellmig Stephan, Bartscht Tobias, Fischbach Wolfgang, Ott Stephan Johannes, Rosenstiel Philip, Klapper Wolfram, Fölsch Ulrich Robert, Schreiber Stefan
Abstract excerpt
Gastric mucosa-associated lymphoid tissue (MALT) lymphoma is a histologically distinct tumour derived from MALT acquired as a result of Helicobacter pylori infection. The genetic susceptibility to develop primary gastric B-cell lymphoma in patients with chronic H. pylori infection is unknown. MALT1 plays a key role in malignant B-cell transformation and lymphoma progression. Thus, we investigated germline...
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