Article
Association of IL-6 gene alleles with systemic lupus erythematosus (SLE) and with elevated IL-6 expression.
Genes and immunity - 1 Sept 1999
Linker-Israeli M, Wallace D J, Prehn J, Michael D, Honda M, Taylor K D, Paul-Labrador M, Fischel-Ghodsian N, Fraser P A, Klinenberg J R
Abstract excerpt
To evaluate the association of alleles of regions having regulatory potential in the IL-6 gene, with SLE, the AT-rich minisatellite in the 3' flanking region and the 5' promoter-enhancer of the IL-6 gene were genotyped by PCR- and RFLP-based methods. The AT-rich minisatellite allele distribution pattern was significantly different in SLE (n = 146) as compared to 139 controls (chi 2(7) = 48.97, P = 0.001,...
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