Article
Association between polymorphisms at the human IL-10 locus and systemic lupus erythematosus.
Tissue antigens - 1 Jun 1997
Eskdale J, Wordsworth P, Bowman S, Field M, Gallagher G
Abstract excerpt
Recent studies have shown elevated IL-10 levels in several rheumatic autoimmune diseases, and particularly in systemic lupus erythematosus (SLE). Such changes may have a genetic basis. We studied two novel polymorphic dinucleotide repeats in the IL-10 promoter region (IL10.G and IL10.R) in order to investigate their possible significance in association with this condition in a group of 56 Caucasian SLE patients...
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