Article
Genetic analysis of the INSL3 gene in patients with maldescent of the testis.
European journal of endocrinology - 1 Feb 2001
Lim H N, Raipert-de Meyts E, Skakkebaek N E, Hawkins J R, Hughes I A
Abstract excerpt
OBJECTIVE: Testicular maldescent is important because it is a common congenital disorder that is associated with an increased risk of infertility and testicular cancer. Murine studies indicate that testicular maldescent can result from disruption of insulin-like factor 3 (INSL3) activity and that it may be more severe when there is concurrent undermasculinisation. Therefore, the INSL3 gene was screened for...
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