Article
A new approach to antiplatelet therapy: inhibitor of GPIb/V/IX-vWF interaction.
Haemostasis - 1 Jan 2000
Ikeda Y, Handa M, Murata M, Goto S
Abstract excerpt
Evidence has been presented that the interaction between von Willebrand factor (vWF) and its platelet membrane receptor, the GPIb/V/IX complex, plays an important role in the pathogenesis of arterial thrombosis. A monoclonal antibody against the A1 domain of vWF has been shown to inhibit thrombus formation in the animal model of arterial thrombosis. Based upon these findings, a new approach to treating arterial...
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