Article
Prognostic value of angiotensin-I converting enzyme I/D polymorphism for nephropathy in type 1 diabetes mellitus: a prospective study.
Journal of the American Society of Nephrology : JASN - 1 Mar 2001
Hadjadj Samy, Belloum Riadh, Bouhanick Béatrice, Gallois Yves, Guilloteau Gérard, Chatellier Gilles, Alhenc-Gelas François, Marre Michel
Abstract excerpt
Angiotensin-I converting enzyme (ACE) regulates renal hemodynamics. Its insertion/deletion (I/D) polymorphism, which determines most of ACE interindividual variance, was proposed as a genetic marker for diabetic nephropathy. A substitution (M235T) polymorphism in angiotensinogen (AGT) may interact with ACE I/D polymorphism for the risk of diabetic nephropathy, but their prognostic values have to be established by...
Topics
- Adult
- Alleles
- Angiotensinogen
- Cohort Studies
- Diabetes Mellitus, Type 1
- Diabetic Nephropathies
- Female
- Follow-Up Studies
- Genetic Markers
- Humans
- Male
- Middle Aged
- Peptidyl-Dipeptidase A