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Article

Single and double mutations in gyrA but not in gyrB are associated with low- and high-level fluoroquinolone resistance in Helicobacter pylori.

Antimicrobial agents and chemotherapy - 1 Dec 2003

Tankovic Jacques, Lascols Christine, Sculo Quentin, Petit Jean-Claude, Soussy Claude-James

Abstract excerpt

In one French hospital the rate of resistance to ciprofloxacin in Helicobacter pylori was 3.3% (2 of 60 strains) in 1999. The six resistant clinical strains (four from 1996 and two from 1999) and three ciprofloxacin-selected single-step mutants studied carried one gyrA mutation but none in gyrB. Clinafloxacin and garenoxacin were the most active fluoroquinolones against these mutants. Occurrence of a second gyrA...

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Identifiers

PMID: 14638505
DOI: 10.1128/AAC.47.12.3942-3944.2003
PMCID: PMC296230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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