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RdxA Diversity and Mutations Associated with Metronidazole Resistance of Helicobacter pylori

21 Mar 2023

Abstract excerpt

The increasing resistance to metronidazole impaired the efficacy of Helicobacter pylori eradication, and increasing the dose of metronidazole was recommended to overcome low-level resistance. For patients infected with highly resistant strains, the current empirical treatments, which generally used metronidazole in double doses or more, appeared impossibly to overcome the resistance and would only increase the...

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PMID: 36943041
DOI: 10.1128/spectrum.03903-22

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