Article
A candidate prostate cancer susceptibility gene at chromosome 17p.
Nature genetics - 1 Feb 2001
Tavtigian S V, Simard J, Teng D H, Abtin V, Baumgard M, Beck A, Camp N J, Carillo A R, Chen Y, Dayananth P, Desrochers M, Dumont M, Farnham J M, Frank D, Frye C, Ghaffari S, Gupte J S, Hu R, Iliev D, Janecki T, Kort E N, Laity K E, Leavitt A, Leblanc G, McArthur-Morrison J, Pederson A, Penn B, Peterson K T, Reid J E, Richards S, Schroeder M, Smith R, Snyder S C, Swedlund B, Swensen J, Thomas A, Tranchant M, Woodland A M, Labrie F, Skolnick M H, Neuhausen S, Rommens J, Cannon-Albright L A
Abstract excerpt
It is difficult to identify genes that predispose to prostate cancer due to late age at diagnosis, presence of phenocopies within high-risk pedigrees and genetic complexity. A genome-wide scan of large, high-risk pedigrees from Utah has provided evidence for linkage to a locus on chromosome 17p. We carried out positional cloning and mutation screening within the refined interval, identifying a gene, ELAC2,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.