Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Response to Kondrashov.

Trends in genetics : TIG - 1 Feb 2001

Keightley P D, Eyre-Walker A

Abstract excerpt

The 'mutational deterministic' hypothesis proposes that a high genomic rate of deleterious mutation (U) might maintain sexual reproduction. Our recent work casts doubt on this, as we estimate a low U for sexually reproducing species with short generation times. Following criticism by Kondrashov, here we defend our methods for estimating U and challenge the mutational deterministic hypothesis.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Evolution
Share to Codon
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Sex Ratio

Source

Identifiers

PMID: 11173115
DOI: 10.1016/s0168-9525(00)02177-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Response to Kondrashov.PMID 11173115Read ↗

Deleterious mutations and the evolution of sex.Semantic proximity Read ↗

Inferring Fitness Effects from Time-Resolved Sequence Data with a Delay-Deterministic Model.Semantic proximity Read ↗

Wanted: A population genetic theory of biological noise regulation.Semantic proximity Read ↗

Upper limit of the rate and per generation effects of deleterious genomic mutations.Semantic proximity Read ↗

<i>In silico</i> experiments uncover a novel mechanism underlying mutation rate evolution in sexually reproducing populationsSemantic proximity Read ↗

In Darwinian evolution, feedback from natural selection leads to biased mutations.Semantic proximity Read ↗

Fine-tuning germline mutation rates across evolution.Semantic proximity Read ↗

Analysis and implications of mutational variation.Semantic proximity Read ↗

The evolution of mutation rates: separating causes from consequences.Semantic proximity Read ↗

On a logical difficulty in the directed mutation debate.Semantic proximity Read ↗

[Non-random randomness].Semantic proximity Read ↗

Leading the dog of selection by its mutational nose.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.