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Article

Keratinocyte migration requires alpha2beta1 integrin-mediated interaction with the laminin 5 gamma2 chain.

Journal of cell science - 1 Feb 2001

Decline F, Rousselle P

Abstract excerpt

Keratinocyte migration is an absolute requirement for correct epithelialization during the process of wound healing. This process requires changes in extracellular matrix ligand expression as well as changes in ligand-binding affinity of the corresponding cellular integrins. In this study, we attempt to understand the role of laminin 5 in migration by investigating the integrin-mediated interactions of migrating...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11171386
DOI: 10.1242/jcs.114.4.811

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Keratinocyte migration requires alpha2beta1 integrin-mediated interaction with the laminin 5 gamma2 chain.PMID 11171386Read ↗

Keratinocyte motility induced by TGF-beta1 is accompanied by dramatic changes in cellular interactions with laminin 5.Semantic proximity Read ↗

Globular domains 4/5 of the laminin alpha3 chain mediate deposition of precursor laminin 5.Semantic proximity Read ↗

Functional Re-expression of laminin-5 in laminin-gamma2-deficient human keratinocytes modifies cell morphology, motility, and adhesion.Semantic proximity Read ↗

Cellular Interaction of Integrin α3β1 with Laminin 5 Promotes Gap Junctional CommunicationSemantic proximity Read ↗

Biological function of laminin-5 and pathogenic impact of its deficiency.Semantic proximity Read ↗

Regulation of biological activity and matrix assembly of laminin-5 by COOH-terminal, LG4-5 domain of alpha3 chain.Semantic proximity Read ↗

Processing of Laminin α Chains Generates Peptides Involved in Wound Healing and Host DefenseSemantic proximity Read ↗

Differential regulation of cellular adhesion and migration by recombinant laminin-5 forms with partial deletion or mutation within the G3 domain of alpha3 chain.Semantic proximity Read ↗

Proteolytic processing of the laminin alpha3 G domain mediates assembly of hemidesmosomes but has no role on keratinocyte migration.Semantic proximity Read ↗

Human amnion contains a novel laminin variant, laminin 7, which like laminin 6, covalently associates with laminin 5 to promote stable epithelial-stromal attachment.Semantic proximity Read ↗

Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin.Semantic proximity Read ↗

Reduced expression of the epithelial adhesion ligand laminin 5 in the skin causes intradermal tissue separation.Semantic proximity Read ↗

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