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Article

Cloning and characterization of mouse glutamine:fructose-6-phosphate amidotransferase 2 gene promoter.

Gene - 31 Dec 2000

Yamazaki K, Mizui Y, Oki T, Okada M, Tanaka I

Abstract excerpt

Glutamine:fructose-6-phosphate amidotransferase (GFAT) is the first and rate-limiting enzyme of the hexosamine biosynthesis pathway, which plays an important role in glucose toxicity and cellular insulin resistance. Thus, the mechanisms by which GFAT expression is regulated under physiological and pathological conditions are of interest in connection with diabetes. In this study, we cloned the 5'-flanking region...

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PMID: 11167021
DOI: 10.1016/s0378-1119(00)00497-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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